In this paper, determination of the design variable optimum values of simple and spliced pre-tensioned girders in bridges is addressed by considering the life cycle cost of the whole structure. To this end, a program called OBPG is written with FORTRAN, consisting of the analysis, design and optimization subroutines based on the feasible direction method. AASHTO principles are used, assuming initial values for the design variables such as the dimensions of the girders and the deck, and the strands number. Then, using the analysis outcomes and considering the design criteria, the total cost of the structure, including that of the girders and slabs concreting, pre-tensioning cables performance, reinforcement and frameworks, are minimized as functions of the design variables. Although the initial optimization cost using life cycle cost is slightly more than that using the initial cost, optimization of the life cycle cost proves to be more economical. Ultimately, a program capable of analyzing simple and spliced pre-tensioned bridge girders is developed which calculates the life cycle and gives an optimum design.